Expanding the Hepatitis E Virus Toolbox: Selectable Replicons and Recombinant Reporter GenomesReview Published on 2023-03-282023-06-12 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] epitope tag infectious clone insertion reporter selection gene subgenomic replicon. [DOI] 10.3390/v15040869 PMC 바로가기 [Article Type] Review
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Independent acquisition of short insertions at the RIR1 site in the spike N-terminal domain of the SARS-CoV-2 BA.2 lineageArticle Published on 2022-09-012022-11-16 Journal: Transboundary and emerging diseases [Category] SARS, 변종, [키워드] acquisition characterized community transmission COVID-19 case Denmark event functional genomic hotspot implication indels independent insertion Lineage lineages Mutation mutations N-terminal domain National Non-synonymous nucleotide sequence occurred omicron Prevalence reached responsible SARS-CoV-2 spike glycoprotein Spread Substitution the SARS-CoV-2 unique viral evolution viral evolution. [DOI] 10.1111/tbed.14672 PMC 바로가기
A feasibility randomised trial comparing therapeutic thoracentesis to chest tube insertion for the management of pleural infection: results from the ACTion trialRandomized Controlled Trial Published on 2022-08-302022-10-05 Journal: BMC Pulmonary Medicine [Category] 임상, [키워드] 1:1 Adult patient Adverse average Chest clinician Completeness complex control group COVID-19 pandemic criteria current defined diagnosed eligible Empyema event feasibility group healthcare Hospital stay Hypothesis in both group inclusion criteria Infection insertion International intravenous antibiotics management mean hospital stay Parapneumonic participant Patient patients pleural effusion Pleural empyema. Primary outcome protocol randomisation randomised Randomised trial readmission recruitment reduce required significantly shorter Standard of care surgical therapeutic Therapies Total treatment allocation Trial were blinded [DOI] 10.1186/s12890-022-02126-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparison of Insertion, Deletion, and Point Mutations in the Genomes of Human Adenovirus HAdvC-2 and SARS-CoV-2Article Published on 2022-08-042023-07-09 Journal: The Tohoku Journal of Experimental Medicine [Category] COVID19(2023년), [키워드] Deletion Human adenovirus insertion Point mutation Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [DOI] 10.1620/tjem.2022.J049 PMC 바로가기
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patientsNF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험Article Published on 2022-08-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased [DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern우려되는 모든 SARS-CoV-2 변이체의 유연한 검출을 위한 다중 단편 분석Article Published on 2022-07-272022-09-11 Journal: Clinical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] ABI Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus allele Analysis analyzed approach approach capillary electrophoresis concern coronavirus cycle threshold deleted Deletion Delta detection effective equipment exhibited fluorescent fragment insertion insertions Lambda limit of detection multiplex mutants omicron ORF1a ORF8 PCR performed primer primer pair primer pairs RDR RDR1 RDR2 RDR3 Receptor binding domain resolved respiratory specimens S-gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity subsequent target variant variants variants of concern VoC VOCs WGS whole genome Whole genome sequencing [DOI] 10.1093/clinchem/hvac081 PMC 바로가기 [Article Type] Article
A Comparison of Bioinformatics Pipelines for Enrichment Illumina Next Generation Sequencing Systems in Detecting SARS-CoV-2 Virus StrainsSARS-CoV-2 바이러스 균주 검출 시 Illumina 차세대 시퀀싱 시스템 강화를 위한 생물정보학 파이프라인 비교Comparative Study Published on 2022-07-262022-09-11 Journal: Genes [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Amino acid bioinformatics bioinformatics pipeline capture method characterization coronavirus 2 coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Critical Deletion downstream enrichment enrichment. full-length SARS-CoV-2 genome Generation Hope Human genome Illumina Indonesia insertion limitation Major mapped mapping metagenomic mutations next generation sequencing NGS normal nucleotide nucleotide substitution nucleotide substitutions pandemic Panel Previous studies previous study reads respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus situation SNPs strain Strains System table the SARS-CoV-2 genome utilization Variation virus worldwide pandemic worsening [DOI] 10.3390/genes13081330 PMC 바로가기 [Article Type] Comparative Study
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화Article Published on 2022-07-072022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type [DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article